Calculator for initiating NAC (N-acetylcysteine) for acetaminophen toxicity. Uses the treatment line (25% reduction from the Rumack-Matthew line).

Pitfall: assumes single time of ingestion, not multiple ingestions over time.

 

PO Dosing of NAC

 

IV Dosing of NAC

 

Rumack, BH and Matthew, H. Acetaminophen poisoning and toxicity. Pediatrics. 1975; 55(6): 871–6.

White SJ and Rumack, BH. The Acetaminophen Toxicity Equations: "Solutions" for Acetaminophen Toxicity Based on the Rumack-Matthew Nomogram. Ann Emerg Med. 2005; 45(5): 563-4.

Cyrstal, Merlin. Acetaminophen treatment line chart. Wikipedia. Accessed Apr 12, 2015.