NINDS Criteria

Inclusion:

Exclusion:

 

ECASS III

Inclusion:

Exclusion: same as NINDS plus

 

Relative contraindications:

 

Studies demonstrating benefit to tPA:

Studies demonstrating no effect or harmful effect to tPA:

Rate of intracranial hemorrhage after tPA: (Predicting sICH. J Neuro Sci. 2013.)

 

Dosing of tPA

 

 

Clinical Policy: Use of Intravenous tPA for the Management of Acute Ischemic Stroke in the Emergency Department. Ann Emerg Med. 2013; 61: 225-243.