Diagnostic score for Disseminated Intravascular Coagulopathy (DIC) as per the International Society on Thrombosis and Haemostasis.

 

Platelet count [x109]
Prothrombin Time (PT) prolongation
Fibrin / fibrin degradation products *

* D dimer:
Upper limit of normal to 4µg/mL = ↑
> 4µg/mL = ↑↑ ("strongly elevated")

 

Exclusion criteria: anticoagulated (heparin, coumadin, etc.) or coagulation disorder

Sensitivity = 91%
Specificity 97%

Validated in an ICU cohort of (mostly surgical) patients where clinicians were concerned for DIC. Score was calculated q48hrs, with the "gold standard" of DIC being expert opinion based on a number of advanced assays not typically available in the clinical setting.

 

Bakhtiari K et al. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004; 32(12): 2416-21.

Taylor FB Jr et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001; 86(5):1327-30.