SOFA = 0

Sequential [Sepsis-Related] Organ Failure Assessment (SOFA) score is designed to replace SIRS as a marker for sepsis.

Urine Output (mL/day)
Cardiovascular

Dopamine, epinephrine, and norepinephrine doses are in µg/kg/min.

 

Evidence of infection with a score increase of ≥ 2 from the patient's baseline = sepsis.

SOFA has not been prospectively validated for use in sepsis (it has been validated for predicting mortality). The goal is to reduce the number of patients being called "septic" based on 2+ SIRS criteria w/ source of infection.

AUROC 0.79 (95% CI, 0.78-0.79) for patients outside of the ICU with suspected infection, compared with 0.76 (95% CI, 0.75-0.77) for SIRS, based on retrospective analysis of multiple data sets.

Use the worst available lab results within the past 24 hours for calculation of the score.

Per the European Society of Intensive Care Medicine and the Society of Critical Care Medicine (2016 Joint Task Force):

 

Singer M et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8): 801-810.